Description

Repeated transfusion of Blood or Red Blood Cells in Thalassaemia Major (TM) patients results in iron  overload causing damage to various organs.  FeriBond is a unique complexing and chelating agent of  natural origin based on natural humato-ferrate complex and small molecular weight gallo-tannoids, which help to facilitate safe removal of excess iron from the body in TM patients.  In FeriBond, the  molar ratio of ligands to iron is more than that of metal ion;  hence excess ferric iron let loose by the system is complexed and chelated with ligands  to  reduce  it  to  ferrous form and to slowly  release ferrous  iron  to 'iron  hungry'  receptors.  The entire process helps to prevent Fenton-type  reaction  and  concomitant  free  radical  induced  damage and optimum utilisation  of  ferrous  iron  as well as excretion  of  excess  iron  from  the  body  through  urine.  Serum  ferritin  levels  are  reduced  by FeriBond in  10-12  weeks  and  with  continued  administration  the  level  remains  low  despite  repeated  blood  transfusions.  Unlike chemical chelators such as desferrioxamine / deferiprone, no long term ill effects have been observed  in  children  on  FeriBond  administration.  Moreover, in TM cases if FeriBond is simultaneously administered with these chemical chelators, their need is gradually reduced and later they can be altogether  withdrawn.  FeriBond is offered as advanced complexation and chelation therapy for TM patients to prevent and treat iron over-load and to maintain and improve haemoglobin level in a safe and affordable  way.

Usage/Indications

In Thalassaemia Major  patients  on  blood  transfusion or packed  RBC transfusion,  to  prevent  and  control  iron  overload  and  maintain  serum ferritin in desirable range.

Dosage